The surveillance

for rotavirus was supported by the Indian Council for Medical Research. The authors thank Dr. Miren Iturriza-Gomara of the University of Liverpool for technical support, training and helpful discussions. Conflicts of interest: None reported. “
“Rotaviruses are enteric pathogens causing acute, watery, dehydrating diarrhea in various host species, including birds and mammals. ATM Kinase Inhibitor mouse Rotavirus is the cause for approximately 500,000 child deaths each year, mainly in developing countries [1]. Likewise, rotavirus-associated enteritis is a major problem in young calves [2]. Besides affecting cattle and buffalo calves, rotaviruses also affect piglets, foals, lambs, and young ones of pet animals and poultry [3], [4] and [5]. The rotavirus genome consists of 11 GDC-0068 clinical trial double-stranded RNA segments and each genome segment encodes at least one protein (VP1–VP4, VP6, and VP7, NSP1 to NSP6) [6]. Traditionally, the rotavirus classification scheme has been based on a dual nomenclature

to differentiate the VP4 (P) and VP7 (G) type specificities encoded by two genome segments, 4 (for VP4) and 7, 8 or 9 (for VP7, depending on the strain). At least 27 G Modulators genotypes and 35 P genotypes based on the sequence analysis of the VP7 and VP4 genes have been identified [7]. Recently, the 11 rotavirus gene segments (VP1, VP2, VP3, VP4, VP6, VP7, NSP1, NSP2, NSP3, NSP4 and NSP5 genes) have been assigned letter codes for each gene and classified into at least 6 R, 6 C, 7 M, 35 P, 13 I, 27 G, 16 A, 6 N, 8 T, 12 E and 8 H genotypes, respectively, based on specific nucleotide sequence identity cut-off percentages for each gene segment [8] and [9]. Human rotaviruses most commonly belong to G types 1–4, 9 and P types [4] and [8] [10] whereas bovine rotaviruses most commonly belong to G types 6, 8 and 10 and ever P types [1], [5], [6] or [11] [11]. G10 strains commonly occur in combination with P[11], P[5] and P[1]

[2]. A G10 P[15] strain was reported for the first time in a lamb infected with rotavirus in China [12]. In India, so far, bovine diarrhea associated with G10 rotavirus has been seen in combination with P[11] [13], [14] and [15], P[6] [16], P[14] [17] and P[3] [18]. Despite clear evidence of host range restriction, a number of animal gene segments, mostly those encoding the neutralizing antigens (defining G and P types), have been identified repeatedly in humans in different parts of the world during surveillance studies [19] and [20], providing evidence that animals may act as a source of virus and/or of genetic material for evolutionary diversification of human rotaviruses. For example, strains such as G3 (found commonly in species such as cats, dogs, monkeys, pigs, mice, rabbits, and horses), G5 (pigs and lambs), G9 (pigs and lambs), and G10 (cattle) have been isolated from the human population throughout the world [10].