The study aims to provide suggestion for the

service planning; as examine the surgeons sub-specialty training who were involved into the emergency operations. Patients and methods Data were collected prospectively AZD6738 manufacturer from all consecutive cases of gastric cancer patients presenting to the Upper Gastro-Intestinal Multidisciplinary Team at The Royal London Hospital between September 2003 and January 2010. Patient demographics, mode of presentation, disease stage at presentation, interventions and treatment undertaken, complications, hospital stay and survival were retrospectively analysed from the Departmental Database. All consecutive patients presenting with gastric cancer to The Royal London Hospital or referred for

treatment from one of the local diagnostic centres were involved. All of them were discussed at the specialised Multidisciplinary Team meeting; patients requiring urgent intervention often were discussed after initiation of treatment. Patients with stage IV disease or those deemed unfit for resection were diverted to a palliative care pathway. Fit patients with resectable disease were treated with curative intent. Neoadjuvant chemotherapy was considered in all patients with T3 or higher stage of cancer (according to the MAGIC trial) [15]. Emergency presentation was defined as those patients whom required immediate admission for treatment of symptoms (bleeding, perforation or this website obstruction). Major bleeding was characterised by the requirement of one or more unit of blood transfusion for acute blood loss. Patients with cancer at the gastro-oesophageal junction were excluded, as were any patients undergoing prophylactic Tyrosine-protein kinase BLK gastrectomy due to hereditary risk of gastric carcinoma. Data was analysed to investigate the effect of emergency presentation upon the stage of disease at presentation and the proportion of patients treated with curative intent. The number of patients requiring

emergency surgical intervention MLN2238 mouse within 24 hours of presentation was recorded. Cumulative survival periods were calculated using the Kaplan-Meier method and differences in survival rates by disease stage were analyzed by COX-regression analysis. Comparison between the emergency and the elective presentations the χ2 test and Fisher’s exact test were used. Results Patient demographics and presentation A total of 291 patients presented to our centre with gastric carcinoma during the 77-month period. Forty-two (14.4%) of these patients presented as an emergency with upper gastrointestinal (GI) bleeding, gastric perforation or gastric outlet obstruction. The remaining 249 patients (85.6%) presented electively via an outpatient referral with non-acute symptoms. The mean age at presentation was 67 years in the emergency group and 68 in the elective group. From the emergency group twenty-five patients presented with obstruction (59.6%), two patients with perforation (4.