The molecularly imprinted polymer (MIP) was synthesized using tyramine as the template molecule, silicic acid tetracthyl ester and triethoxyphenylsilane as the functional monomers. The molecularly imprinted film displayed excellent selectivity towards tyramine. Under the optimum conditions, the current response had a linear relationship with the concentration

of tyramine in the range of 1.08 x 10(-7) to 1 x 10(-5) mol/L, with a limit of detection 5.7 x 10(-8) mol/L. The proposed sensor exhibited excellent repeatability, which was better than the result from previous literature. The relative selleck chemical standard deviation (RSD) of the repeated experiments for tyramine (5 mmol/L) was 7.0%. Determination of tyramine in real samples showed good recovery. (C) 2010 Elsevier Ltd. All rights reserved.”
“The anticonvulsant drug lacosamide selectively enhances slow inactivation of voltage-gated sodium channels and has been shown to be an effective PF-562271 Angiogenesis inhibitor add-on treatment for partial-onset seizures. Common adverse events (frequency >= 10%) of lacosamide doses up to 600 mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence). There are no human data regarding the safety of very high dosages

of lacosamide. We report the clinical course of a patient with bitemporal epilepsy who ingested 12 g of lacosamide, 56 g of gabapentin, 2 g of topiramate, and 2.8 g of zonisamide during a suicide attempt. The patient was found comatose and experienced repeated generalized tonic-clonic seizures, aspiration with subsequent pneumonia, hypotension, and an increase in PR interval. Complete physical recovery occurred after several days of supportive treatment. We conclude that intoxication with lacosamide, in combination with overdoses of multiple AEDs, can be survived without sequelae, even after ingestion of 12 g lacosamide. (C) 2010 Elsevier Inc. All rights reserved.”
“Composites of poly(n-buthyl acrylate) (PnBA) and eutectic metallic

alloy composed of Bi, In, and Sn were prepared by mechanically mixing them above the melting point of the metallic alloy, and glass transition temperature of PnBA. The heating curves of differential scanning calorimetry (DSC) of the composite of PnBA and the metallic alloy showed an endothermic peak below the EX 527 Epigenetics inhibitor melting point of the metallic alloy without polymers, which indicated the formation of the interfacial phases of the metallic alloy with a lower melting point. The exothermic peaks of the cooling curves were broadened and shifted to the temperature lower than the melting point of the metallic alloy without polymers, which suggests that the crystallization of the metallic alloy was suppressed by the interaction. The mechanism of lowering the melting points and suppression of the crystallization was discussed based on the results of DSC, transmitting electron microscopy, and X-ray diffractometry. (C) 2010 Wiley Periodicals, Inc.