Results: A total of 2275 participants HDAC inhibitor were included in this study (629 patients with adenomatous polyps and 1,646 polyp-free

controls). Old age (p < 0.01), male gender (p < 0.01), current cigarette smoker (p < 0.01), or current alcohol drinker (p = 0.01), and high BMI (>25 kg/m2), Family history of colorectal cancer (p = 0.022) were associated with the development of sporadic colorectal neoplasm of 40s patients. In the point of view of a family history of malignant neoplasm, colorectal cancer (OR:1.50, CI:1.05–2.14), kidney cancer (OR:2.55, CI:1.00–6.50) were associated with adenomas development especially more than 3 adenomas. Family history of colorectal cancer is associated with advanced adenoma development (OR:3.02, CI:1.42–6.40) at the multivariate analysis adjusted for sex, age, BMI, smoking and alcohol check details consumption. Especially, colon adenoma is more affected than rectal adenoma by family history of colorectal cancer. Conclusion: This study shows family history of colon cancer, family history of kidney cancer were a risk factor for the colorectal adenoma in persons aged 40–49 years. Therefore, earlier screening

colonoscopic surveillance might be needed for individual 40–49 years aged relatives than none of family history. Key Word(s): 1. colorectal neoplasm; 2. aged 40–49 years; 3. colon cancer; 4. kidney cancer; Table 2 The association between family history of cancer and risk for colorectal adenomas according to the location of adenomas   Colon Rectum (n = 564) (n = 98) N (%) OR* (95% CI) N (%) OR* (95% CI) *Adjusted for sex, age, BMI, smoking status, alcohol consumption Presenting Author: RASOUL SOTOUDEHMANESH Additional Authors: NAIMEH NEJATI, MARYAM FARSINEJAD,, SHADI KOLAHDOOZAN, ROYA RAHIMI, JAVAD MIKAELI, MORTEZA KHATIBIAN Corresponding Author: RASOUL SOTOUDEHMANESH Affiliations: digestive DiseaseResearchCenter; Digestive Disease Research Center Objective: Not infrequently, the usual imaging modalities fail to identify the cause of CBD dilation and

endoscopic ultrasonography (EUS) becomes necessary. The aim of this study was to assess the value of EUS in identifying the cause of CBD dilatation undiagnosed by transabdominal ultrasonography Methods: During 18 months, 152 consecutive patients who were referred for evaluation medchemexpress of dilated CBD (diameter ≥7 mm) discovered incidentally during transabdominal ultrasonography were included. Final diagnoses were confirmed by ERCP, EUS-guided FNA, surgical exploration, or clinical follow up of at least 10 months. Patients with choledocholithiasis were referred for ERCP and sphincterotomy, and patients with operable tumors were referred for surgery. Patients with inoperable tumors underwent biliary stenting with or without chemoradiotherapy. Results: One hundred and fifty (54% female) with dilated CBD were included. Mean age of patients was 60 ± 17 years. The final diagnoses was choledocholithiasis in 32 (21.