Of these reactors, only 1 control dog, 1 newly-diagnosed diabetic

Of these reactors, only 1 control dog, 1 newly-diagnosed diabetic dog and 3 insulin-treated diabetic dogs recognised porcine insulin by ELISA, suggesting that the remaining

proinsulin reactors might have been recognising proinsulin-specific epitopes.

Conclusions and clinical relevance: This study suggests that proinsulin autoantibodies are present in a proportion of diabetic dogs. Further work is required to refine the assay and clarify the significance of these autoantibodies. (C) 2010 Elsevier Ltd. All rights reserved.”
“Background: Information on efficacy and predictors of response to adalimumab in ulcerative selleck inhibitor colitis (UC) clinical practice is limited.

Aim: Assessment of response to adalimumab and its predictors in an observational cohort study.

Methods: Retrospective cohort study based on data obtained from ENEIDA registry. All patients diagnosed with UC treated with adalimumab were included. Response to adalimumab was evaluated at weeks 12, 28, and 54 according to the partial Mayo score, and requirement of colectomy until end of follow-up.

Results: 48 patients with UC treated with adalimumab were included; 39 (81.3%) had previously received infliximab. Response

rates at weeks 12, 28 and 54 were 70.8%, 43.2% and 35% respectively. Response to prior treatment with infliximab was the only predictive factor of response to adalimumab at week 12, which was obtained in 90% of infliximab remitters, 53.8% of responders and 33.3% of primary

non-responders (p = 0.01).

Colectomy click here was required in 11 patients (22.9%), after a mean time of 205 days. The only clinical independent predictor of colectomy was non-response to adalimumab at week 12: colectomy rates were 5/34 (14.7%) in responders and 6/14 GSK923295 (42.9%) in non-responders (p = 0.035), time free of colectomy was significantly reduced in non-responders (p=0.01). Adalimumab withdrawal due to adverse events occurred in 4.2% of patients.

Conclusion: This study shows that adalimumab is an effective treatment in patients with UC. If used as a second anti-TNF, previous achievement of remission with the first anti-TNF predicts response, and failure to achieve response at week 12 predicts colectomy. (C) 2012 European Crohn’s and Colitis Organisation. Published by Elsevier B.V. All rights reserved.”
“Here we present a study of the electronic structure of epitaxial ferromagnetic Mn(5)Ge(3)(0001) films on Ge(111) by means of x-ray absorption spectroscopy, x-ray photoelectron spectroscopy, and spin-resolved photoelectron spectroscopy. Spin-polarization (P) value of +(15 +/- 5)% at the Fermi energy (E(F)) is measured with a photon energy of h nu = 21.2 eV. Our findings are in contrast to recent band structure calculations, predicting P=-41% at E(F) for the ferromagnetic bulk Mn(5)Ge(3). (C) 2009 American Institute of Physics. [DOI: 10.1063/1.

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