Development of a loop capable of exerting a continuous compressive force may reduce bleeding risk. Tumor removal by the RLUB technique was confirmed on EUS in 12 patients with follow-up. Two patients with focal thickening of the muscularis propria underwent FNA sampling and had no residual tumor

cells. Long-term follow-up is needed to determine whether the RLUB technique is truly curative.21 In conclusion, this pilot study establishes proof-of-concept of a novel platform for full-thickness treatment of stromal tumors by ligation. Limitations encountered included technical challenges and delayed bleeding that require further development work. http://www.selleckchem.com/products/PTC124.html “
“Endoscopic transluminal treatment of pancreatic fluid collections (PFCs) is an effective alternative to surgical treatment.1 and 2 After endosonography-guided puncture, drainage, irrigation, or direct endoscopic necrosectomy (DEN) may be performed, depending on the PFC status.3 The success rate, mortality, and length of hospital stay associated with Trichostatin A this minimally invasive treatment are superior to those for conventional surgical treatment,4 and 5 thereby resulting in improved mortality of severe pancreatitis.4 and 6 A new, fully covered, self-expandable, metal stent (FCSEMS) for pancreatic

fluid collections (PFCs) is short enough to perform direct endoscopic necrosectomy, and it has a wide flare to prevent migration. Pancreatic pseudocyst usually is treated by using drainage and/or irrigation. A plastic stent used for drainage is susceptible to obstruction and migration, leading Non-specific serine/threonine protein kinase to a recurrence of symptoms. In the treatment of walled-off pancreatic necrosis (WOPN),

DEN is often used for the removal of the solid necrotic component.7 However, several sessions of DEN may be required. Multiple plastic stents are used to drain pancreatic fluid and to maintain an adequate tract size. Peritonitis caused by leakage between the enteric and cystic walls may occur. To overcome these problems, a fully covered, self-expandable, metal stent (FCSEMS) has been used instead of multiple plastic stents.8, 9 and 10 However, most reports involve a biliary or esophageal stent. Few reports concerning a specialized FCSEMS for gastrocystostomy are available.11 and 12 Between December 2011 and July 2012, 9 patients underwent endoscopic treatment for PFC with the use of the new FCSEMS. All the procedures were carried out on an inpatient basis. The stent was inserted by two skilled endoscopists (H.I. and H.K.) in two hospitals. After the treatment, the patients were followed-up in 4 hospitals under consultation with the operator. All patients provided written, informed consent, and the study was approved by our institute’s review board.