(C) 2011 Japanese Society for Investigative Dermatology Publishe

(C) 2011 Japanese Society for Investigative Dermatology. Published

by Elsevier Ireland Ltd. All rights reserved.”
“A selleck chemicals case of avascular necrosis of whirlbone in a young man affected by multiple sclerosis and treated with high doses of corticosteroids is described. The authors discuss the causes of this collateral effect underlining the risks of underevaluating the symptoms.”
“Background: Atrial action potential duration (APD) has been shown to decrease with increasing distance from the sinoatrial node in several species, including humans. This gradient has been postulated to be cardioprotective by reducing repolarization gradients.

Objectives: This study tests the effect of the APD gradient on reentry initiation and characteristics.

Methods: This study used a geometrically accurate atrial computer model to examine arrhythmogenic consequences of an APD gradient on reentry initiation by ectopic beats applied at several locations. As well, dominant frequency maps of any ensuing reentries were analyzed to determine how APD gradients affected rotor behaviour.

Results: When the APD gradient was increased, anatomic reentry that used the coronary sinus as a critical pathway was prevented, but initiation

of functional reentry was unaffected. If a rotor did form, APD gradients led to more disorganized behaviour. For rotors circulating around A-1155463 the pulmonary veins, discrete interatrial coupling accounted for left atrium-right atrium frequency gradients, irrespective of an APD gradient.

Conclusions: Gradients are protective against anatomic reentry but also increase the complexity of arrhythmias IPI-145 manufacturer that arise.”
“Thrombocytopenia is a major adverse effect of several drug treatments.

Rifampicin has been recognized as a cause of immune thrombocytopenia. A 68-year-old woman diagnosed with pulmonary tuberculosis was taking the standard four-drug antituberculosis regimen for 4 months. She presented with decreased responsiveness and headache. Brain MRI revealed subdural hemorrhage along the falx cerebri and high convexity. The platelet count was 8,000 mu L(-1). Intracranial hemorrhage due to rifampicin-induced thrombocytopenia has not, to our knowledge, been previously reported. We report a patient with acute subdural hemorrhage associated with rifampicin-induced thrombocytopenia.”
“As the world’s population ages, hip fractures pose a significant health care problem. Hip fractures in the elderly are associated with impaired mobility, and increased morbidity and mortality. Associated conditions, such as osteoporosis, medical comorbidity, and dementia, pose a significant concern and determine optimal treatment. One-year mortality rates currently range from 14% to 36%, and care for these patients represents a major global economic burden. The incidence of hip fractures is bimodal in its distribution.

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