But for each of them, there is an overwhelming sense of delight and

appreciation to have participated in what Edmond Fischer describes as a most fruitful and rewarding experience, in which I received far more than I could give. Through their experiences they have truly bonded both in fellowship and friendship alike, fulfilling Bert and Kuggie Vallee’s vision for the program. Having witnessed at first hand the response of twenty-six distinguished scientists to the experience of traveling to other institutions for a brief, but intense time, and enjoying the pleasures that accompanied the visits, we cannot but believe that, after many decades accomplishing a large amount of sterling work, Bert Vallee has left a lasting legacy that will benefit Trametinib chemical structure this website many people. “
“This article is written in honour of Bert Vallee. Others will write a history of his life but I shall write only about my experience of exchanging views and working with him. I shall then concentrate upon where this contact has led me until today. The central theme will be the biological chemistry of zinc and then its evolution. Much of the later part of this paper will be a summary of parts of a book entitled “Evolution’s Destiny” with Dr. Rosalind Rickaby of the Earth Sciences Department

at the University of Oxford, which has been accepted for publication by the Royal Society of Chemistry, UK. Bert Vallee and I met following a series of exchanges by letter after he had come across my paper “Metal Ions in Biological Systems” RAS p21 protein activator 1 in 1953 [1]. He pointed out that I had not referred to his article “Zinc in White Blood Cells” [2]. We exchanged a few letters which had an element of claiming priority to the origin of studies of Biological Inorganic Chemistry. Any disagreement was resolved when he came to a Faraday Society Meeting in Oxford in 1955 which led to our collaborative work until 1970. He told me then of his discovery of zinc in carboxypeptidase which, with the prior knowledge of zinc in carbonic anhydrase and his work on zinc in blood,

opened the field of zinc biochemistry [3]. I discovered that one of his analytical methods for zinc determination used the organic reagent dithizone which had been used by me as a student of Dr. H.M.N.H. Irving in 1947–48 to understand the principles behind analytical methods using such organic reagents for metal ion quantitative analytical determination [4]. I also examined the possibility of quantitative analysis for all the metal ions from Mn2 + to Zn2 + with the same reagent, dithizone [4]. The work showed that all the six elements could be analysed by this reagent but the strength of interaction between metal ion and dithizone followed a series. Checking this series against those of complex ion formation in solution and against other organic reagents used in analysis by extraction or precipitation, I found that there was one series of binding for them all, now known as the Irving-Williams series, Fig. 1, [5] and [6].