8% vs. 30.3%), abdominal pain (28.7% vs. 9.9%), hard stool (45.8% vs. 34.1%), and straining (59.1% vs. 55.3%) compared to Asians. Prucalopride treatment was consistently and significantly (p < 0.001) more effective than placebo in relieving bloating, hard stool and straining in both Asians and non-Asians with mild to very severe baseline symptoms. For abdominal pain, treatment effects were numerically consistent across the subgroups. Conclusion: More severe CC-associated symptoms were observed among non-Asians compared to Asians. Twelve-week treatment with prucalopride 2-mg improved CC associated

symptoms in both Asian and non-Asian patients, regardless of the severity of baseline symptoms. Key Word(s): 1. Chronic Constipation; 2. Prucalopride; Presenting Author: MARJORIE STELWAGON Additional Authors: S. MACHELLE MANUEL, BALAZS FELCSUTI, REBEKAH Erismodegib HOCH Corresponding Author: MARJORIE STELWAGON Affiliations: Ironwood Pharmaceuticals, Inc.; EMD Serono, Inc. Objective: This quantitative survey was conducted to assess frequency and bothersomeness of Irritable Bowel Syndrome with Constipation (IBS-C) symptoms, healthcare seeking behavior, and treatment satisfaction in China. Methods: An adult sample (aged 18+) in tier 1, 2, and 3 cities in China meeting modified

ROME II criteria for IBS-C completed in-person interviews regarding the frequency and bothersomeness of symptoms, healthcare seeking behavior, and medication satisfaction; bothersomeness and satisfaction NVP-BEZ235 research buy were rated using 5-point Likert scales. Exclusion criteria included IBD, diverticulitis,

PUD, GI cancers; ≤junior high school; and income <2000 RMB. The survey population included 130 respondents who had sought physician care in the last 12 months (50 diagnosed, 40 undiagnosed) and 40 respondents who had not sought care. Results: The most frequent symptoms were straining (116 days/yr), incomplete evacuation (103 days/yr), lack of predictability, and bloating (Table). Forty-eight percent found their abdominal symptoms “extremely/very 上海皓元 bothersome” and 43% found their constipation symptoms “extremely/very bothersome”. Persistent constipation and abdominal symptoms were primary triggers for seeking care. Among respondents seeking care in the last 6 months, only 7% were “extremely” or “very” satisfied with current therapies. Conclusion: IBS-C sufferers in China experience frequent and bothersome abdominal and constipation symptoms, which are the main drivers to seek care. Most patients are not very satisfied with current treatments, highlighting the need for options that target the multiple symptoms associated with IBS-C. Research has not been published elsewhere, was conducted by Livingston Market Consultants and C1 Consulting, and was funded by Ironwood Pharmaceuticals, Inc. Key Word(s): 1. IBS-C; 2. constipation; 3. abdominal pain; 4. bloating; Table.