32 (SD 0.45) and 2.56 (SD 2.71) mL, respectively. The median follow-up period of patients was 44.3 (range, 1–77.5) months. Treatment-related complications occurred in 7 (9.6%) patients; massive variceal bleeding during the EVO in 3 (4.1%), septic thrombophlebitis in 1 (1.3%), pulmonary embolism in 1 (1.3%), intraperitoneal leakage of cyanoacrylate in 1 (1.3%), symptomatic splenic infarction in 1 (1.3%). By Kaplan-Meier analysis, the cumulative rebleeding rate were 3.4%, 14.1%, 25.4% and 33.8% at 1, 12, 36 and 60 months respectively. By univariate analysis, Child-Pugh class C liver function was associated with increased rate of rebleeding. However,

no independent risk factor for rebleeding was identified by multivariable analysis. find more Conclusion: EVO using N-butyl-2-cyanoacrylate for bleeding fundal varices shows favorable long-term effectiveness and safety profile. Key Word(s): 1. Fundal varices; 5-Fluoracil 2. Variceal obturation; 3. Cyanoacrylate; Presenting Author: JIANGYUAN WANG Additional Authors: YULAN LIU Corresponding Author: YULAN LIU Affiliations: Department of Gastroenterology, Peking University People’s Hospital Objective: To explore the etiology, clinical features and prognostic factors of hepatorenal syndrome (HRS) in cirrhosis patients with ascites. Methods: A retrospective analysis was performed on clinical data of 74

patients with HRS admitted to Peking University People’s Hospital from August 2007 to December 2012. Clinical features and laboratory findings were compared before and after onset of HRS. Survival curves of HRS were estimated by Kaplan-Meier method, and multivariable Cox proportional hazards 上海皓元 model was used to analysis the predictive

factors of death. Results: Totally 74 patients were included in this study, with a male-female ratio of 3.6:1 and mean age of 64 ± 13. Patients with Child-Pugh A, B and C are 0(0%), 10(13.5%) and 64(86.5%), respectively. There are 42(56.8%) patients with type I HRS and 32(43.2%) with type II. Infection, upper gastrointestinal hemorrhage and electrolyte disorder are the main risk factors of HRS, and 67(90.5%) patients had one or more precipitating factors. Significant differences of CRE, BUN, GFR, TBIL, DBIL, ALB, INR, Na, Child-Pugh classification and MELD score are found between before and after the onset of HRS. There are significant differences of NE, CRE, BUN, GFR, TBIL, DBIL, INR, Child-Pugh classification and MELD score between two types of HRS. The median survival time of type I and type II HRS are 7 days and 120 days respectively (P < 0.001). In single-factor Cox proportional hazards model, CRE, BUN, GFR, TBIL, DBIL, INR, MELD score are all associated with prognosis. According to multivariable Cox model, only MELD score is associated with prognosis (P < 0.001, OR = 1.078). Conclusion: HRS usually occurs in end-stage live disease with some precipitating factors, and can greatly deteriorate liver and renal function.