At 48 weeks, 90% receiving

DTG versus 83% PFT�� supplier receiving DRV/r was virologically suppressed. The adjusted difference Selleckchem Blasticidin S of 7.1% (95% CI 0.9–13.2%) and P = 0.025 in ITT analysis establishes DTG as both non-inferior and statistically superior to DRV/r. Virologic failure (>200 copies/mL) occurred in two participants in each study arm, and no primary mutations were captured. When stratified by baseline viral load, those with HIV RNA >100,000 copies/mL (~25%) revealed an even greater distinction with 93% of those in the DTG arm suppressed versus 70% in the DRV/r arm. Fewer adverse events and withdrawals occurred in the DTG group, and likely contributed to statistical superiority [34] (Fig. 2). Clinical Trials of Dolutegravir in Treatment of ART-Experienced

Patients In SAILING (NCT01231516), ART-experienced, INSTI-naïve participants were randomized (1:1) to 50-mg daily DTG or 400-mg twice-daily RAL plus investigator-selected background therapy. SAILING was the first and thus far only DTG study to include resource-limited settings. Treatment was double-blinded, active-controlled, and designed as a non-inferiority study with statistical superiority analysis [35]. At week 48, 71% receiving DTG versus 64% receiving RAL demonstrated virologic suppression selleck kinase inhibitor <50 copies/mL, meeting non-inferiority as well as superiority criteria [35]. Treatment-emergent resistance to the background regimen, 3% RAL and <1% DTG, and to INSTI, 5% RAL and 1% DTG. No phenotypic resistance Methocarbamol to DTG was reported. VIKING

(NCT00950859) was the first study to evaluate DTG activity among participants with genotypic RAL resistance in a standard 50-mg daily dose (Cohort 1) [22]. During this study, a protocol amendment to include a cohort receiving twice-daily 50-mg DTG was created to compare efficacy (VIKING Cohort 2). Twice-daily dosing was found to be more efficacious both at day 10 (96% versus 78% for the primary endpoint of ≥0.7 log10 copies/mL change from baseline in HIV-1 RNA or <400 copies/mL) and at week 24 after optimizing the background regimen (OBR) (75% versus 41% with HIV-1 RNA <50 copies/mL). Those with viral mutations including Q148H/K/R plus G140S plus additional RAL mutations had a reduced response to DTG. VIKING-3 (NCT01328041) further investigated the use of DTG in treating INSTI-experienced participants failing their current regimen (viral load >500 copies/mL). DTG was substituted for the first-generation INSTI, acting essentially as functional monotherapy until day 8 when OBR occurred [23]. On day 8 of DTG 50 mg twice daily, the average change of HIV-1 RNA from baseline was −1.43 log10 copies/mL (95% CI −1.52, −1.34). DTG was continued with OBR with at least one active drug on day 8, with 69% achieving <50 copies/mL at week 24, and 63% at week 48 [36].