4%) and asymptomatic carotid artery stenosis. CEA was performed in 253 patients, whereas 251 patients received endovascular treatment (mainly angioplasty alone). This study excluded high-risk patients, and stents were used selectively, when available, and in only 26% of cases (n = 55). During a median carotid ultrasound follow-up time of 4 years patients undergoing endovascular treatment were found to suffer significantly more often from severe restenosis

(≥70%) or occlusion than patients after CEA [15]. When comparing balloon angioplasty alone to angioplasty and stenting, those patients who were treated with a stent (n = 50) had a significantly lower risk of developing restenosis of ≥70% (adjusted hazard ratio 0.43, 0.19–0.97; p = 0.04). Regarding the clinical complications in patients with a restenosis, the incidence of ipsilateral stroke or transient ischemic attack was significantly

Target Selective Inhibitor Library cell line higher in patients with a restenosis ≥70% (cumulative 5-year incidence 22.7% vs. 10.9%, p = 0.04) compared to those with no ISR. Current or past smoking turned out to be independently associated with a higher incidence of restenosis [15]. The Stent-Supported Percutaneous Angioplasty of the Carotid Artery vs. Endarterectomy Trial (SPACE) assessed non-inferiority of CAS to CEA and randomized 1183 patients (CAS n = 605; CEA n = 595) with a symptomatic carotid artery stenosis as assessed with duplex ultrasound (≥50% according SD-208 datasheet to NASCET criteria, or ≥70% according to ECST criteria) at 35 centres in Austria,

Germany and Switzerland [1]. The type of stent and use of a protection system were chosen at the discretion of the interventionalist. Restenosis during follow-up were observed more frequently in those patients treated with CAS (4.6% vs. 10.7%, p < 0.001) compared to CEA [16]. The majority of the recurrent stenosis occurred within the first 6 months after the initial treatment (CAS n = 28 (51.9%), CEA n = 12 (52.2%)). Furthermore, additional new ISR were observed even after 24 months of follow-up after carotid stenting whereas no new recurrent restenosis was found after CEA beyond 2 years of follow-up. Because a predefined definition of ISR GNE-0877 was not used during the study period and the definition of an ISR depends on the local criteria of each center, a slight overestimation of ISR might be possible [16]. Endarterectomy versus angioplasty in patients with symptomatic severe carotid stenosis (EVA-3S) trial [2] was carried out to demonstrate non-inferiority of CAS compared with CEA and enrolled 527 patients with ≥60% symptomatic carotid stenosis at 30 centres in France. In 507 patients (CAS n = 242, CEA n = 265) serial long-term carotid ultrasound follow-up was performed during a mean follow-up time of 2.1 years [17]. Although the development of a moderate stenosis (≥50–69%) within 3 years was found to differ significantly between the groups with a higher proportion after CAS compared to CEA (12.5% vs.